Meat: Grows the Brain or Rusts the Body?

Back in the day, in 1946, we were right to like meat, it was the fun way to get our proteins, it came in cans. Sometimes with a sack of sauce! And people knew meat was good, but thanks to the American Meat Institute, they then learned that it was this good. Fast forward to […]

Insulin, carbohydrates and the IGF-1 pathway’s role in cancer and aging | Peter Attia

[Peter]: Okay. So that’s the easy story. Now the hard one, IGF. Okay. So two schools of thought on this, I am in one camp but I will acknowledge the other camp. One camp says IGF-1 is driven exclusively by amino acids. The other camp says, no, it’s actually driven by amino acids and carbohydrates. […]

The connection between Alzheimer’s disease and insulin resistance | Peter Attia

[Rhonda]: Yeah. So what are your thoughts as to what are triggering Alzheimer’s disease in terms of our environment? [Peter]: Yeah. I mean, I think it’s probably a combination of things. But the most compelling evidence to me and, again, this is probably, because I’m just a simpleton and I like to start with Occam’s […]

Lifestyle factors that affect Alzheimer’s risk for APOE4 carriers | Peter Attia

[Rhonda]: There’s a huge, huge component for lifestyle in risk for Alzheimer’s disease, particularly with having an ApoE4 allele, and that’s where I’ve become obsessed. You know, I’ve been looking at mechanism but also looking at the epi studies. Looking at epidemiology, you see certain lifestyle factors for example, drinking. If you’re drinking in your […]

MEAT — CANCER, carcinogens, cooking, and processing (#1)

According to the World Cancer Research Fund, in a report written in 2007, red meat and processed meat increase the risk of colorectal cancer, and possibly also of many others: esophageal, pulmonary, pancreatic, endometrial, gastric, and prostatic. To be clear, “red meat”, in this report and here, refers to beef, pork, lamb, and goat from […]

Lactate and beta-hydroxybutyrate in the treatment of traumatic brain injury | Peter Attia

Meal timing and late eating as a modulator of cancer risk and risk-associated biomarkers

[Rhonda]: So these three factors that are known, the fasting, high-fasting insulin, the high free estrogen… [Ruth]: Right. [Rhonda]: …and the high inflammatory markers. [Ruth]: Right. [Rhonda]: So as measured by certain biomarkers like C-reactive protein. [Ruth]: Right. [Rhonda]: So these are all associated with, in some, cases even two to threefold increased risk. [Ruth]: […]

Shorter telomeres can be transmitted epigenetically to offspring | Elissa Epel

– [Rhonda]: And there are some human diseases where telomeres are short and that does have a progeria type of effect, like Werner. – [Elissa]: Right. So that’s super interesting. So in these certain handful of genetic disorders, where people might have half a dose for telomerase, so their telomeres shorten quickly, they develop diseases […]

Non-pharmaceutical approach to lowering hemoglobin A1c using time-restricted eating | Ruth Patterson

[Rhonda]: A couple of points that you mentioned, I just want to circle back to the glycated hemoglobin you mentioned, that basically fasting in the evening had a pretty robust effect in reducing that. [Ruth]: Yeah. [Rhonda]: And that’s a marker obviously, it’s a marker of your long-term, you know, blood glucose levels. [Ruth]: Absolutely, […]