Serine Family & Methionine Catabolism – Biochemistry | Lecturio

The next amino acid metabolism family I want to consider is that of the serine family. So, the serine family, as the other families are described, uses serine as a central amino acid for branching out to make the other amino acids. So to understand this family, I need to first describe how serine is […]

Proline & Arginine Synthesis – Biochemistry | Lecturio

That next amino acid we consider in biosynthesis is that a proline. Proline is made in a relatively simple fashion in three steps starting from glutamate. The first step involves the synthesis of glutamate-5-semialdehyde which I don’t show here. The first step beyond that then is the phosphorylation of the glumate-5-semialdehyde. That oxidation and dephosphorylation […]

α-ketoglutarate Family & Glutamine Synthesis – Biochemistry | Lecturio

I want to start a discussion here talking about the alpha-ketoglutarate family, also called the glutamate family because all of the amino acids that are made in this family include glutamate and alpha-ketoglutarate as precursors. Now, this is a very good place to start our discussion because the alpha-ketoglutarate family starts with the process that’s […]

Nucleotide Metabolism: Introduction and De novo Purine Metabolism – Biochemistry | Lecturio

Virtually every school kid today learns that ATP, GTP, CTP, and UTP are the nucleotide building blocks used to make RNA and the deoxyribonucleotide versions of those are the building blocks used to make DNA. What they don’t know and what you probably haven’t learned is how those nucleotides themselves are made, and that will […]

Amino Acid Metabolism: Introduction – Biochemistry | Lecturio

In this set of lectures, I will describe the most diverse set of metabolic processes that occur that of amino acid metabolism. Now to review for just a second, we remember that amino acids are essential for making proteins and that there are 20 common amino acids that are found in all proteins plus an […]